Microbiome & Chronic Diseases

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Obesity (Diet induced) ⇒ Obesity {40000117}

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Obesity (Diet induced)


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Endocrinology, DietNutrition
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- Lactobacillus plantarum suppresses the production of leptin.(4)

Shared Notes

  • [1.2
    - Long-term consumption of highly processed foods by pregnant women has been shown to alter gut microbial diversity and relative abundances in the newborn, and exposure of infants to such foods can influence appetite preferences and eating habits that persist throughout life
  • [1.3
    - Obesity alters the balance of Firmicutes in non-obese individuals to Bacteroidetes phyla in obese ones.
  • [1.4
    - Infants fed with breast milk rich in betaine showed reduced growth rates after birth.
    - Experiments in mice showed that giving betaine to female mice improved blood sugar metabolism and lowered fat tissue in breastfeeding offspring.
    - When breast-fed with milk rich in betaine, both mouse pups and human infants had higher amounts of Akkermansia bacteria in their guts.
    - Low levels of maternal betaine during pregnancy are linked to increased infant weight at birth.
    - Maternal betaine supplementation resulted in lower fetal weight in a mouse study.
  • [1.5
    - Mediterranean-style diet is highly encouraged because of its healthy dietary pattern, which includes antioxidant nutraceuticals such as polyphenols. Indeed, hydroxycinnamic derivatives, quercetin, resveratrol, oleuropein and hydroxytyrosol, which are well known for their antioxidant and anti-inflammatory activities, exert anti-obesity proprieties.
  • [1.6
    - High-fat diet and obesity are associated with increased Firmicutes and decreased Bacteroidetes
  • [1.8
    - SPF mice that received a high-fat diet did gain weight. This diet quickly boosted the abundance of certain microbes in the small intestine, including microbes from the Clostridiaceae and Peptostreptococcaceae families. A member of Clostridiaceae was found to specifically impact fat absorption. The abundance of other bacterial families decreased on a high-fat diet including Bifidobacteriacaea and Bacteriodacaea, which are commonly associated with leanness.
  • [1.9
    - Lactobacillus casei can improve insulin resistance which is the underlying cause of obesity-associated metabolic abnormalities, in diet-induced obesity (DIO) mice.
  • [1.10
    - These changes in Akkermansia muciniphila were robustly correlated with the expression of lipid metabolism and inflammation markers in adipose tissue, as well as several circulating parameters (i.e., glucose, insulin, triglycerides, leptin) from DIO mice.

Common References