Schizophrenia | Disease

Schizophrenia {40000115}

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Definition:	Schizophrenia
Class:	[ ]

Details
Other Terms:	SCZ
Authoring date:	2020-09-06

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Wickipedia Merck Manual

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ICD:	[ ]
Category:	Psychiatric
MedDra ID:	10039626
MedDra Level:	pt

Notes

- Host-genetic-driven increases in Enterobacteriaceae family and Enterobacteriales order were potentially related to a higher risk of SCZ, while Gammaproteobacteria class was related to a lower risk of SCZ
- Gut production of serotonin was potentially associated with a higher risk of SCZ.
- There is a strong relationship of lower platelet serotonin concentrations with depressive symptoms of SCZ.
- According to the principle of brain plasticity, glutamate signals are destroyed by serotonergic overdrive, leading to neuronal hypometabolism, synaptic atrophy, and gray matter loss in the end.
- Enterobacteriaceae family and Enterobacteriales order can produce SCFAs (e.g., acetic acid and formic acid) in carbohydrate fermentation, thus inducing serotonin biosynthesis by enterochromaffin cells which are the major producers of serotonin, and ultimately increasing the risk of SCZ.
- Porphyromonadaceae were associated with poor cognitive performance.
- Gut inflammation can induce activation of microglia and the kynurenine pathway, which activate systemic inflammation-inducing depressive or schizophrenic symptoms (1)

Increased abundance of

‐ Actinomyces Faeces ‎Human [1.1]

‐ Akkermansia muciniphila Faeces ‎Human [1.2, 1.3]

‐ Alkaliphilus oremlandii Faeces ‎Human [1.2]

‐ Anaerococcus Faeces ‎Human [1.4]

‐ Anaerotruncus Faeces ‎Human [1.1]

‐ Bacteroidaceae Faeces ‎Human [1.5]

‐ Bacteroides fragilis Faeces ‎Human [1.6]

‐ Bacteroides plebeius Faeces ‎Human [1.2]

‐ Bifidobacterium adolescentis Faeces ‎Human [1.2, 1.3]

‐ Bifidobacterium breve Swab throat ‎Human [1.7]

‐ Bifidobacterium dentium Faeces ‎Human [1.2]

‐ Bifidobacterium longum Faeces ‎Human [1.2]

‐ Bifidobacterium pseudocatenulatum Swab throat ‎Human [1.7]

‐ Bilophila Faeces ‎Human [1.1]

‐ Blautia Faeces ‎Human [1.1]

‐ Burkholderiaceae Faeces ‎Human [1.1]

‐ Catenibacterium mitsuokai Swab throat ‎Human [1.7]

‐ Chaetomium Faeces ‎Human [1.1]

‐ Christensenella Faeces ‎Human [1.1]

‐ Clostridium Faeces ‎Human [1.6]

‐ Clostridium innocuum Faeces ‎Human [1.1]

‐ Clostridium perfringens Faeces ‎Human [1.3]

‐ Clostridium symbiosum Faeces ‎Human [1.2]

‐ Collinsella aerofaciens Faeces ‎Human [1.6]

‐ Coriobacteriaceae Faeces ‎Human [1.5]

‐ Cronobacter sakazaki Faeces ‎Human [1.2]

‐ Deferribacter Faeces ‎Human [1.8]

‐ Dialister invisus Faeces ‎Human [1.2]

‐ Dorea Faeces ‎Human [1.1]

‐ Eggerthella Faeces ‎Human [1.1, 1.3]

‐ Eisenbergiella Faeces ‎Human [1.1]

‐ Enterobacteriaceae ‎Deteriorative ‎Gut Lumen ‎Human

‐ Enterobacteriales ‎Deteriorative ‎Gut Lumen ‎Human

‐ Enterococcus faecium Faeces ‎Human [1.2]

‐ Escherichia Faeces ‎Human [1.9]

‐ Eubacterium hallii Swab throat ‎Human [1.7]

‐ Eubacterium hallii Faeces ‎Human [1.1]

‐ Eubacterium siraeum Faeces ‎Human [1.2]

‐ Flavonifractor Faeces ‎Human [1.1]

‐ Gammaproteobacteria ‎Preventive ‎Gut Lumen ‎Human

‐ Haematonectria Faeces ‎Human [1.1]

‐ Halorubrum Faeces ‎Human [1.8]

‐ Halothiobacillus Faeces ‎Human [1.8]

‐ Holdemania Faeces ‎Human [1.1]

‐ Hungatella Faeces ‎Human [1.1]

‐ Klebsiella Faeces ‎Human [1.6]

‐ Lactobacillus Faeces ‎Human [1.8]

‐ Lactobacillus fermentum Faeces ‎Human [1.2]

‐ Lactobacillus gasseri Faeces ‎Human [1.3]

‐ Lactobacillus gasseri Swab throat ‎Human [1.7]

‐ Lactobacillus oris Faeces ‎Human [1.2]

‐ Lactobacillus salivarius Swab throat ‎Human [1.7]

‐ Megasphaera Faeces ‎Human [1.6]

‐ Megasphaera elsdenii Faeces ‎Human [1.3]

‐ Methanobrevibacter Faeces ‎Human [1.6]

‐ Mortierella Faeces ‎Human [1.1]

‐ Ochrobactrum Faeces ‎Human [1.8]

‐ Oscillibacter Faeces ‎Human [1.1]

‐ Parasutterella Faeces ‎Human [1.1]

‐ Patescibacteria Faeces ‎Human [1.1]

‐ Porphyromonadaceae ‎Deteriorative ‎Gut Lumen ‎Human

‐ Prevotellaceae Faeces ‎Human [1.5]

‐ Ruminococcus gnavus Faeces ‎Human [1.1]

‐ Saccharophagus Faeces ‎Human [1.8]

‐ Shigella Faeces ‎Human [1.9]

‐ Sphingomonadaceae Faeces ‎Human [1.3]

‐ Streptococcus gordonii Swab throat ‎Human [1.7]

‐ Streptococcus salivarius Faeces ‎Human [1.2]

‐ Streptococcus thermophiles Swab throat ‎Human [1.7]

‐ Streptococcus vestibularis Faeces ‎Human [1.2]

‐ Succinivibrio Faeces ‎Human [1.6]

‐ Synergistetes Faeces ‎Human [1.1]

‐ Tropheryma Faeces ‎Human [1.8]

‐ Veillonella Faeces ‎Human [1.9]

‐ Veillonella atypica Faeces ‎Human [1.2]

‐ Veillonella dispar Faeces ‎Human [1.2]

‐ Veillonella parvula Faeces ‎Human [1.2]

‐ Veillonellaceae Faeces ‎Human [1.5]

Decreased abundance of

‐ Actinobacillus Faeces ‎Human [1.9]

‐ Agathobacter Faeces ‎Human [1.1]

‐ Alcaligenaceae Faeces ‎Human [1.3]

‐ Anabaena Faeces ‎Human [1.8]

‐ Aspergillaceae Faeces ‎Human [1.1]

‐ Bionectriaceae Faeces ‎Human [1.1]

‐ Blautia producta Faeces ‎Human [1.6]

‐ Butyricicoccus Faeces ‎Human [1.1]

‐ Cephalotrichum Faeces ‎Human [1.1]

‐ Clostridium Faeces ‎Human [1.4]

‐ Coprococcus Faeces ‎Human [1.1, 1.6]

‐ Enterobacteriaceae Faeces ‎Human [1.5]

‐ Enterococcus Faeces ‎Human [1.3]

‐ Erysipelotrichaceae ‎Gut Lumen ‎Human

‐ Eubacterium ventriosum Faeces ‎Human [1.1]

‐ Faecalibacterium Faeces ‎Human [1.1]

‐ Fusicatenibacter Faeces ‎Human [1.1]

‐ Fusobacterium Faeces ‎Human [1.9]

‐ Gallionella Faeces ‎Human [1.8]

‐ Glomerellales Faeces ‎Human [1.1]

‐ Haemophilus Faeces ‎Human [1.4]

‐ Hypocreaceae Faeces ‎Human [1.1]

‐ Lachnospiraceae Faeces ‎Human [1.1, 1.5]

‐ Leuconostocaceae Faeces ‎Human [1.3]

‐ Megasphaera Faeces ‎Human [1.9]

‐ Microascaceae Faeces ‎Human [1.1]

‐ Nitrosospira Faeces ‎Human [1.8]

‐ Ophiostomataceae Faeces ‎Human [1.1]

‐ Purpureocillium Faeces ‎Human [1.1]

‐ Rhodocyclaceae Faeces ‎Human [1.3]

‐ Rikenellaceae Faeces ‎Human [1.3]

‐ Roseburia faecis Faeces ‎Human [1.6]

‐ Ruminococcaceae Faeces ‎Human [1.5]

‐ Ruminococcus gauvreauii Faeces ‎Human [1.1]

‐ Scedosporium Faeces ‎Human [1.1]

‐ Sutterella Faeces ‎Human [1.4]

‐ Trichoderma Faeces ‎Human [1.1]

Schizophrenia {40000115}

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