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Microbiome & Chronic Diseases

Evidence Based Medicine
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Disease ⇒ Gestational diabetes {40000236}

Record Keys


Type:
Disease
Definition:
Gestational diabetes
Parent:[  ]

Details


Initialisation date:[  ]
Other Terms:
GDM

Meta Information


MedDra ID:
10018209
MedDra Level:
pt
ICD:[  ]
Category:[  ]
Zone:[  ]
Mechanism:[  ]

Notes:


[  ]

Shared Notes


  • [1.5
    - Gut microbiota, such as Ruminococcaceae, Parabacteroides distasonis, and Prevotella, were enriched in women with GDM. - - These microbiota populations are associated with metabolic pathways for carbohydrate metabolism and insulin signaling, suggesting a potential “gut microbiota signature” in women with GDM.
  • - Elevated expression of serum zonulin, a marker of gut epithelial permeability, during early pregnancy in women with GDM indicates a possible link between gut microbiota and GDM.
  • [1.6
    - Metabolomics revealed elevated plasma kynurenine at G15/19 in all three mouse strains. IDO1, the rate limiting enzyme for kynurenine production, had increased intestinal expression at G15, which was associated with mild systemic and gut inflammation.