MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine
Sign in

Disease ⇒ Gestational diabetes {40000236}

Record Keys


Type:
Disease
Definition:
Gestational diabetes
Parent:[  ]

Details


Initialisation date:[  ]
Other Terms:
GDM

Meta Information


MedDra ID:
10018209
MedDra Level:
pt
ICD:[  ]
Category:[  ]
Zone:[  ]
Mechanism:[  ]

Notes:


[  ]

References Notes


[  ]

Shared Reference Notes


  • [1.5
    - Gut microbiota, such as Ruminococcaceae, Parabacteroides distasonis, and Prevotella, were enriched in women with GDM. - - These microbiota populations are associated with metabolic pathways for carbohydrate metabolism and insulin signaling, suggesting a potential “gut microbiota signature” in women with GDM.
  • - Elevated expression of serum #Zonulin, a marker of gut epithelial permeability, during early pregnancy in women with GDM indicates a possible link between gut microbiota and GDM.
  • [1.6
    - Metabolomics revealed elevated plasma #kynurenine at G15/19 in all three mouse strains. IDO1, the rate limiting enzyme for #kynurenine production, had increased intestinal expression at G15, which was associated with mild systemic and gut inflammation.
  • [1.7
    - GDM mycobiota > almost exclusively by the Ascomycota phylum. - Kluyveromyces, Metschnikowia, and Pichia showed a significantly higher frequency in GDM patients, while Saccharomyces , were more prevalent in controls. - From T2 to T3, a reduction in fungal alpha diversity was found in GDM patients, with an increase of the relative frequency of Candida, and the reduction of some pro-inflammatory taxa.