Microbiome & Chronic Diseases

Evidence Based Medicine
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Anxiety {40000113}

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Class:[  ]


Other Terms:
Generalized Anxiety Disorder
Initialisation date:


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ICD:[  ]
MedDra ID:[  ]
MedDra Level:[  ]


- Bifidobacterium longum increase of BDNF levels and normalization of behavior. (1)
- Bifidobacterium infantis exaggerated HPA stress response (1)

Shared Notes

  • [1.1
    - Stress and anxiety are related to gut dysbiosis.
    - Ingesting Lactobacillus plantarum P-8 (P-8) improved stress/anxiety symptoms.
    - Symptoms were relieved by modulating gut microbiota and neuroactive potential.
  • [1.3
    - Combination of probiotics and polyphenol-rich prebiotics, a synbiotic >attenuates the chronic-stress induced inflammatory responses in the ileum and the prefrontal cortex promoting > resilience to the consequent depressive- and anxiety-like behaviors in male mice.
    - This effect may be attributed to specific synbiotic-produced metabolites including 4-hydroxyphenylpropionic, 4-hydroxyphenylacetic acid and caffeic acid > promoted anti-inflammatory activity through the aryl hydrocarbon receptor (AHR).
  • [1.2
    - Lactobacillus reuteri and Bifidobacterium adolescentis Probitica > reduction in depressive symptoms at four and eight weeks of treatment, and anxiety symptoms at four weeks.
    > improvement in sleep quality.
    - Lactobacillus reuteri and Bifidobacterium adolescentis Probitica > decrease in serum interleukin-6 levels.
    - Lactobacillus reuteri and Bifidobacterium adolescentis Probitica > increased Bifidobacteriaceae and Lactobacillacea, whereas it decreased Enterobacteriaceae in the gut microbiota composition.

[Coverage other Diseases (Overlap > 0.25)]

DiseaseOverlapCommon increased OrganismCommon decreased Organism
Anxiety 1.0000 3 (100%) : Bifidobacterium longum | Campylobacter jejuni | Lactobacillus plantarum 1 (100%) : Bifidobacterium infantis
Parkinson's Disease 0.3333 2 (67%) : Bifidobacterium longum | Lactobacillus plantarum 0 (0%)