Generalized Anxiety Disorder
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- Bifidobacterium longum increase of BDNF levels and normalization of behavior. (1)
- Bifidobacterium infantis exaggerated HPA stress response (1)
- Stress and anxiety are related to gut dysbiosis.
- Ingesting Lactobacillus plantarum P-8 (P-8) improved stress/anxiety symptoms.
- Symptoms were relieved by modulating gut microbiota and neuroactive potential.
- Combination of probiotics and polyphenol-rich prebiotics, a synbiotic >attenuates the chronic-stress induced inflammatory responses in the ileum and the prefrontal cortex promoting > resilience to the consequent depressive- and anxiety-like behaviors in male mice.
- This effect may be attributed to specific synbiotic-produced metabolites including 4-hydroxyphenylpropionic, 4-hydroxyphenylacetic acid and caffeic acid > promoted anti-inflammatory activity through the aryl hydrocarbon receptor (AHR).
- Lactobacillus reuteri and Bifidobacterium adolescentis Probitica > reduction in depressive symptoms at four and eight weeks of treatment, and anxiety symptoms at four weeks.
> improvement in sleep quality.
- Lactobacillus reuteri and Bifidobacterium adolescentis Probitica > decrease in serum interleukin-6 levels.
- Lactobacillus reuteri and Bifidobacterium adolescentis Probitica > increased Bifidobacteriaceae and Lactobacillacea, whereas it decreased Enterobacteriaceae in the gut microbiota composition.